By developing innovative single-cell lineage tracing technologies, we explore cellular behaviors, lineage relationships, and tissue architecture in unprecedented detail. Our findings have significantly advanced understanding of stem cell dynamics, developmental origins, and regenerative capabilities, challenging traditional views of tissue maintenance and providing new insights into the mechanisms underpinning health and disease.

Central to our research is the goal of translating these fundamental insights into clinical advancements. In hematopoiesis, we have revealed novel progenitor populations and lineage dynamics, offering innovative strategies to enhance bone marrow transplantation, rejuvenate aging immune systems, and prevent hematological malignancies. In liver biology, our focus on cellular plasticity and epigenetic regulation is uncovering pathways that can be targeted to enhance regenerative processes, offering promising approaches for treating chronic liver diseases, fibrosis, and liver cancer.

By bridging basic research and clinical application, our lab remains committed to developing therapeutic strategies that leverage the body's innate regenerative capacities. Our discoveries provide the foundation for new clinical approaches aimed at improving patient outcomes in regenerative medicine and oncology.

Congrats to Li for her paper “ A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells” in Cell Magazine!

Congrats to Dr. Camargo for being appointed as the first Regenerative Biology Chair through the Department of Pediatrics at Boston Children’s Hospital!

Congrats to Debra for her exciting paper in “Cell Stem Cell!’

Three labs @BCHStemCell track blood stem cells ‘in the wild’ to inform better treatments: 

https://discoveries.childrenshospital.org/blood-stem-cells-live-action/ 

Congratulations to Constantina Christodoulou on the publication of her paper “Live-animal imaging of native haematopoietic stem and progenitor cells” in Nature!

Click on her name to read the article!

Congratulations to Jackie Russell on receiving a research fellowship award from the Cholangiocarcinoma Foundation (CCF)!

Congratulations to Alejo Rodriguez-Fraticelli on receiving the K99/R00 Transition to Independence Award, by the National Heart Lung and Blood Institute (NHLBI)!

Congratulations to Fernando Garcia-Osorio on the publication of his Manuscript, Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis, in Cell Reports journal!

Congratulations to Priscilla Cheung for her reception of the F31 Fellowship from the National Cancer Institute!

Congratuations to Dejan Maglic on the publication of his Manuscript, YAP-TEAD signaling promotes basal cell carcinoma development via a c-JUN/AP1 axis, in The EMBO Journal